{"id":173,"date":"2022-01-21T10:57:18","date_gmt":"2022-01-21T01:57:18","guid":{"rendered":"https:\/\/www.honjo-chem.co.jp\/en\/?post_type=products&#038;p=173"},"modified":"2022-02-17T14:27:08","modified_gmt":"2022-02-17T05:27:08","slug":"contract-organic-synthesis","status":"publish","type":"products","link":"https:\/\/www.honjo-chem.co.jp\/en\/products\/contract-organic-synthesis\/","title":{"rendered":"Contract organic synthesis"},"content":{"rendered":"\n<ul class=\"wp-block-list\"><li>We offer a wide range of contract manufacturing services for pharmaceutical, electronic, and other intermediates, centered on the ultra-low temperature reacting facility installed within the Naoshima Organic Chemical Plant.<\/li><\/ul>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"ultra-low-temperature-reaction-80\">Ultra-low temperature reaction (-80\u2103)<\/h1>\n\n\n\n<p>There are reactor made of glass lining (GL) and stainless steel (SUS316) that can handle temperatures as low as -80\u2103, and each reactor can be set to an infinitely variable temperature.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"reaction-made-by-using-various-organometallic-compounds-such-as-butyllithium-etc\">Reaction made by using various organometallic compounds such as butyllithium, etc.<\/h1>\n\n\n\n<p>We have a wealth of experience in reactions using n-butyl lithium, s-butyl lithium, LDA (lithium diisopropylamide), LHMDS (lithium hexamethyldisilazide), etc. Reaction control (increasing selectivity) is possible since coupling agents can be cooled in advance at ultra-low temperatures. In addition, it is possible to perform water-inhibition reactions using metallic lithium, LiAlH<sub>4<\/sub>, NaBH<sub>4<\/sub>, NaH, etc. Other specialty products are also available.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"806\" height=\"304\" src=\"https:\/\/www.honjo-chem.co.jp\/en\/wp-content\/uploads\/sites\/2\/prod_jutaku_p01.jpg\" alt=\"\" class=\"wp-image-206\" srcset=\"https:\/\/www.honjo-chem.co.jp\/en\/wp-content\/uploads\/sites\/2\/prod_jutaku_p01.jpg 806w, https:\/\/www.honjo-chem.co.jp\/en\/wp-content\/uploads\/sites\/2\/prod_jutaku_p01-500x189.jpg 500w, https:\/\/www.honjo-chem.co.jp\/en\/wp-content\/uploads\/sites\/2\/prod_jutaku_p01-300x113.jpg 300w, https:\/\/www.honjo-chem.co.jp\/en\/wp-content\/uploads\/sites\/2\/prod_jutaku_p01-768x290.jpg 768w\" sizes=\"auto, (max-width: 806px) 100vw, 806px\" \/><\/figure><\/div>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"quality-control\">Quality Control<\/h1>\n\n\n\n<p>The company handles contract manufacturing of pharmaceutical and other intermediates in compliance with GMP quality control system.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"main-facility\">Main Facility<\/h1>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.honjo-chem.co.jp\/wp-content\/uploads\/prod_jutaku_p02.jpg\" alt=\"\" class=\"wp-image-388\" \/><figcaption>Ultra-low temperature reacting facility<\/figcaption><\/figure><\/div>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"reactor\">Reactor<\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Capacity<\/th><th>Material Design<\/th><th>Temperature<\/th><\/tr><\/thead><tbody><tr><td>500L<\/td><td>GL<\/td><td>-80 to 120\u2103 <\/td><\/tr><tr><td>1200L<\/td><td>GL<\/td><td>-80 to 120\u2103 <\/td><\/tr><tr><td>2000L<\/td><td>GL<\/td><td>-20 to 120\u2103 <\/td><\/tr><tr><td>3000L<\/td><td>GL<\/td><td>-80 to 120\u2103<\/td><\/tr><tr><td>3000L<\/td><td>SUS316<\/td><td>-80 to 120\u2103 <\/td><\/tr><tr><td>4000L<\/td><td>GL<\/td><td>-20 to 120\u2103<\/td><\/tr><tr><td>5000L<\/td><td>GL<\/td><td>-80 to 120\u2103<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Other equipment includes centrifuges, pressure filtration equipment, and vibratory decompression dryers.<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","class_list":["post-173","products","type-products","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.honjo-chem.co.jp\/en\/wp-json\/wp\/v2\/products\/173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.honjo-chem.co.jp\/en\/wp-json\/wp\/v2\/products"}],"about":[{"href":"https:\/\/www.honjo-chem.co.jp\/en\/wp-json\/wp\/v2\/types\/products"}],"author":[{"embeddable":true,"href":"https:\/\/www.honjo-chem.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"wp:attachment":[{"href":"https:\/\/www.honjo-chem.co.jp\/en\/wp-json\/wp\/v2\/media?parent=173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}