- We offer a wide range of contract manufacturing services for pharmaceutical, electronic, and other intermediates, centered on the ultra-low temperature reacting facility installed within the Naoshima Organic Chemical Plant.
Ultra-low temperature reaction (-80℃)
There are reactor made of glass lining (GL) and stainless steel (SUS316) that can handle temperatures as low as -80℃, and each reactor can be set to an infinitely variable temperature.
Reaction made by using various organometallic compounds such as butyllithium, etc.
We have a wealth of experience in reactions using n-butyl lithium, s-butyl lithium, LDA (lithium diisopropylamide), LHMDS (lithium hexamethyldisilazide), etc. Reaction control (increasing selectivity) is possible since coupling agents can be cooled in advance at ultra-low temperatures. In addition, it is possible to perform water-inhibition reactions using metallic lithium, LiAlH4, NaBH4, NaH, etc. Other specialty products are also available.
![](https://www.honjo-chem.co.jp/en/wp-content/uploads/sites/2/prod_jutaku_p01.jpg)
Quality Control
The company handles contract manufacturing of pharmaceutical and other intermediates in compliance with GMP quality control system.
Main Facility
![](https://www.honjo-chem.co.jp/wp-content/uploads/prod_jutaku_p02.jpg)
Reactor
Capacity | Material Design | Temperature |
---|---|---|
500L | GL | -80 to 120℃ |
1200L | GL | -80 to 120℃ |
2000L | GL | -20 to 120℃ |
3000L | GL | -80 to 120℃ |
3000L | SUS316 | -80 to 120℃ |
4000L | GL | -20 to 120℃ |
5000L | GL | -80 to 120℃ |
Other equipment includes centrifuges, pressure filtration equipment, and vibratory decompression dryers.